The first road closures go into effect at 7am and the last until as late as 7pm in places.
Artillery Place, Charlton Park Lane, Charlton Road, Charlton Way, John Wilson Street, Little Heath and Shooters Hill Road are all scheduled to be reopened by midday on Sunday.
By contrast Birdcage Walk, Byward Street, Upper Thames Street and Victoria Embankment will be shut for the full 12 hours.